It works with my Mac
I can say that I dont have the problemt hat Joe Hair has experienced. I have played the game for almost 12 hours and I am not seeing of his problems. I have a Mac Pro with 3 monitors attached 20" Apple Cinema, 24" Apple LED Cinema, and the 30" Apple Cinema HD displays. It is true that the beginning of the game does take up the full screen using the main screen, but you can adjust that after you complete the intro scene and provide your name (as did the previous Luxor). There are setting in the game to use the display as "WINDOWED" and I adjusted the resolution to 1600x1000. After that I never had any probelms. I am still on the first game (as I have not died yet).
So no problems. I gave it 3 stars because I thought it was a little pricey given the limited content. I was hoping to see more than 1 mode other than the main game and a free play round.
Good game though as I have the previous Luxor game. So if you are a fan of Luxor, I would get this one.
dangsite about LUXOR: Quest for the Afterlife